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[博士论坛]:慢性自发性荨麻疹患者血循环中白介素17和C反应蛋白浓度的关系

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sopherezhang 发表于 2017-10-23 11:25:41 | 显示全部楼层 |阅读模式



作者 A. Grzanka et al
期刊名称 Allergy, Asthma & Clinical Immunology
发表时间 2017-5-10
Allergy Asthma ClinImmunol (2017) 13:25  DOI 10.1186/s13223-017-0197-6
本文来自:https://www.ncbi.nlm.nih.gov/pubmed/?term=The+relationship+between+circulating+concentrations+of+interleukin+17+and+C+reactive+protein+in+chronic+spontaneous+urticaria

The relationship between circulating concentrationsof interleukin 17 and C reactive protein in chronic spontaneous urticaria
慢性自发性荨麻疹患者血循环中白介素17C反应蛋白浓度的关系

Background 背景: Up-regulation of interleukin 17 (IL-17) family cytokinesand acute phase response have been observed in patients with chronicspontaneous urticaria (CSU). It has been demonstrated that IL-17 stimulatesC-reactive protein (CRP) expression.
研究发现,慢性自发性荨麻疹(CSU)患者血循环中白介素17(IL-17)家族细胞因子和急相反应均有升高。IL-17已被证实可刺激C反应蛋白(CRP)的表达。

Aim 目的: To determine relationship between circulatingconcentrations of IL-17 and CRP in CSU.
确定CSU患者血循环中IL-17和CRP的关系。
Methods 方法 : Concentrations of IL-17 in plasma and CRP in serum weremeasured in patients with CSU of varying severity and in the healthy subjects.
在不同严重程度的CSU患者和健康受试者中,测量他们血浆中IL-17和血清中CRP中的浓度。
Results 结果: IL-17 and CRP concentrations were significantly higher inCSU patients as compared to the healthy subjects. In addition, there weresignificant differences in IL-17 and CRP concentrations between CSU patientswith mild, moderate-severe symptoms and the healthy subjects. CRP did notcorrelate significantly with IL-17.
与健康的受试者相比,CSU患者的IL-17和CRP的浓度明显更高。此外,不同严重程度患者和健康受试者之间的IL-17和CRP浓度之间存在显著差异。CRP与IL-17之间没有显著的相关性。
Conclusions 结论: Increased circulating IL-17 concentration may representan independent index of systemic inflammatory response in CSU, which is notrelated to increased CRP concentration.
IL-17浓度升高可能代表了CSU患者中一个独立的系统炎症反应指数,这与CRP浓度的增加无关。

博士三教班 张小敏 31700042



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