请选择 进入手机版 | 继续访问电脑版
设为首页收藏本站

老西部英语

 找回密码
 立即注册

只需一步,快速开始

高脂饮食增加了肠系祖细胞的干性和致瘤性

1

主题

1

资源

10

积分

新手上路

Rank: 1

积分
10
水木目 发表于 2016-11-27 19:54:46 | 显示全部楼层 |阅读模式
本帖最后由 水木目 于 2016-11-27 19:54 编辑

文章出处:Nature, 2016, 531(7592), 53-58
题目:High-fat diet enhances stemness and tumorigenicity of intestinal progenitors
作者:Semir Beyaz, Miyeko D. Mana1, Jatin Roper1, Dmitriy Kedrin, Assieh Saadatpour, Sue-Jean Hong
期刊名称:Nature
发表时间:2016-03-03
本文来自:https://www.ncbi.nlm.nih.gov/pubmed/?term=High fat+diet+enhances+stemness+and+tumorigenicity+of+intestinal+progenitors

摘要:
Little is known about how pro-obesity diets regulate tissue stem and progenitor cell function. Here we show that high-fat diet (HFD)-induced obesity augments the numbers and function of Lgr5(+) intestinal stem cells of the mammalian intestine.Mechanistically, a HFD induces a robust peroxisome proliferator-activated receptor delta (PPAR-δ) signature in intestinal stem cells and progenitor cells (non-intestinal stem cells), and pharmacological activation of PPAR-δ recapitulates the effects of a HFD on these cells. Like a HFD, ex vivo treatment of intestinal organoid cultures with fatty acid constituents of the HFD enhances the self-renewal potential of these organoid bodies in a PPAR-δ-dependent manner.Notably, HFD- and agonist-activated PPAR-δ signalling endow organoid-initiating capacity to progenitors, and enforced PPAR-δ signalling permits these progenitors to form in vivo tumours after loss of the tumour suppressor Apc.These findings highlight how diet-modulated PPAR-δ activation alters not only the function of intestinal stem and progenitor cells, but also their capacity to initiate tumours.

翻译:
人们对于“肥胖症饮食是如何调控组织干细胞和系祖细胞的作用?”这一问题知之甚少。通过此文,我们证明了:高脂饮食诱发的肥胖增加了所标记肠道的肠干细胞中Lgr5(+)富含亮氨酸重复序列的G蛋白偶联受体5)的数量并增强了其功能。机械地,高脂饮食导致了肠干细胞和系祖细胞中强PPAR-δ(过氧化物酶体增殖物激活受体信号,同时用药物激活PPAR-δ概括了高脂饮食对这些细胞的影响。用高脂饮食中的脂肪酸组分对肠类器官进行离体培养,这同高脂饮食一样通过依赖PPAR-δ的方式增强了这些内器官的自我更新潜能。值得注意的是,高脂饮食激活的和激活剂激活的PPAR-δ信号使得祖细胞具有形成类器官的能力,同时增强的PPAR-δ信号使得这些祖细胞在敲除了原癌基因A后在体内成为肿瘤。这些发现高度揭示了饮食因素激活了PPAR-δ后,如何改变肠干细胞和系祖细胞的功能,及如何改变它们的致瘤性。
硕士四教班 梁湘婧  21600413

友荐云推荐
评论

使用道具 举报

QQ|关于我们|联系我们|网络条款|建议反馈|小黑屋|老西部英语 ( 版权所有 粤ICP备11103350号  

GMT+8, 2019-8-23 04:11 , Processed in 0.202314 second(s), 31 queries .

Powered by Discuz! X3

© 2001-2013 Comsenz Inc.